Antiviral and Therapeutic Effects of a Mixture of <i>Boswellia serrata</i>, <i>Commiphora myrrha</i>, and Propolis for SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly affects tracts including the trachea and lungs. As inflammation cytokine storm are major pathological features in a Syrian hamster for SARS-CoV-2 infection, reducing inflammatory responses or antiviral therapy is an effective strategy treating infections. Herbal medicines natural substances applied worldwide due to their health-beneficial effects. Although chemical pharmacological verifications have not been made all substances, effects of many being studied. In this study, Boswellia serrata, Commiphora myrrha, propolis known anti-inflammatory antimicrobial properties were selected as candidates therapeutic herbal medicine targeting SARS-CoV-2. When mixture was treated infected Vero E6 Calu-3 cells, demonstrated. Next, administered SARS-CoV-2-infected hamsters, histopathological lesions significantly reduced. Viral spike protein viral enzyme gene also less detected immunohistochemistry quantitative real-time PCR results, respectively. Thus, it can be concluded that has potential reduce upon infection.